TCA and Phenol Peels: What Can We Learn From Photoaged Hairless Mice?

April 02, 2013 | Category: Anti-aging treatments, Cosmetic dermatology
TCA and Phenol Peels: What Can We Learn From Photoaged Hairless Mice?

Gary Goldenberg, MD

Dr. Goldenberg is Assistant Professor, Department of Dermatology, Mount Sinai School of Medicine, New York, New York, and Medical Director of the Dermatology Faculty Practice, New York (http://www.goldenbergdermatology.com).

Dr. Goldenberg reports no conflicts of interest in relation to this post.

 

A study published in the International Journal of Dermatology (2011;50:1075-1082) evaluated skin rejuvenation effects of trichloroacetic acid (TCA) and phenol peels in photoaged hairless mice. Photoaged skin exhibits deep coarse wrinkles, dryness, telangiectasia, skin atrophy, and hyperpigmentation. Three types of chemical peels are currently used: superficial type, penetrates and damages the papillary dermis (TCA 10%–30%); medium type, penetrates and damages the upper reticular dermis (TCA 50%); deep type, penetrates and damages the lower reticular dermis (phenol, Baker-Gordon peel formula). The mechanism by which peels improve photoaged properties of skin is not fully understood. 

[More]

Liquid Facelift With Sculptra

Liquid Facelift With Sculptra

Gary Goldenberg, MD

Dr. Goldenberg is Assistant Professor, Department of Dermatology, Mount Sinai School of Medicine, New York, New York, and Medical Director of the Dermatology Faculty Practice, New York (http://www.goldenbergdermatology.com).

Dr. Goldenberg reports no conflicts of interest in relation to this post.

 

A review published in the Aesthetic Surgery Journal (2011;31:95-109) highlighted the use of poly-L-lactic acid (PLLA)(Sculptra Aesthetic, Valeant Aesthetics, a division of Valeant Pharmaceuticals North America) for nonsurgical rejuvenation of the aging face and restoration of facial volume. The nonsurgical, or liquid, facelift has become increasingly popular and use of PLLA is one of the cornerstones of this procedure.  

[More]

Dosing of OnabotulinumtoxinA for Hyperdynamic Perioral Rhytides

Dosing of OnabotulinumtoxinA for Hyperdynamic Perioral Rhytides

Anthony M. Rossi, MD

Dr. Rossi is a Fellow in Procedural Dermatology and Mohs Surgery, Memorial Sloan-Kettering and Weill Cornell/New York-Presbyterian Hospital, both in New York, New York.

Dr. Rossi reports no conflicts of interest in relation to this post.

 

The September 2012 issue of Dermatologic Surgery (2012;38:1497-1505) featured a randomized double-blind study to compare the safety, efficacy, and dose-response relationship of 2 doses of onabotulinumtoxinA for the treatment of hyperdynamic perioral rhytides. Sixty female participants were randomized in a 1:1 ratio to receive either 7.5 or 12.0 U of onabotulinumtoxinA at 4 perioral sites. Participants were then assessed at weeks 2, 4, 8, 12, 16, and 20. The severity of the perioral lines and participant satisfaction were assessed at all visits.

[More]

Month List

Tag Cloud