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Original Article

Orlistat-Induced Bullous Leukocytoclastic Vasculitis

Lazic T, Fonder M, Robinson-Bostom L, Wilkel CS, Della Torre L

Cutis. 2013;91:148-149.

Cutaneous leukocytoclastic vasculitis (LCV), also known as small-vessel vasculitis, is a process thought to be related to the presence of circulating immune complexes. Leukocytoclastic vasculitis is thought to be idiopathic in up to 50%of cases, but other common causes and associated disorders include certain medications, most frequently antibiotics; infections;collagen-vascular disease; paraproteinemias; and rarely neoplasia. We report a patient with cutaneous LCV induced by orlistat, a pancreatic lipase inhibitor that works as a weight-loss agent by decreasing the absorption of dietary fat.


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