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Original Article
The Pathophysiology of Acne Vulgaris in Children and Adolescents, Part 2: Tailoring Treatment
Bergfeld WF
Cutis
. 2004;74:189-192.
Various pathophysiologic factors are involved in the development of acne lesions, microcomedones, comedones, and inflammatory lesions. These factors include follicular hyperkeratosis, increased colonization of follicles by
Propionibacterium acnes,
increased sebum production, and inflammatory mediators. Optimal treatment of acne involves the use of agents that address these various underlying pathogenetic factors.
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