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Original Article
Basic Fibroblast Growth Factor Treatment for Skin Ulcerations in Scleroderma
Yamanaka K-i, Inaba T, Nomura E, Hurwitz D, Jones DA, Hakamada A, Isoda K, Kupper TS, Mizutani H
Cutis
. 2005;76:373-376.
We report the use of topical application of recombinant human basic fibroblast growth factor (rhbFGF) to successfully treat therapy-resistant, chronic leg ulcers in scleroderma. Endothelial cell FGF receptors are directly stimulated by bFGF; also, bFGF promotes the regeneration of capillary-rich granulation tissue. We conclude that topical bFGF may be a powerful new pharmacologic tool for treating severe skin ulcers.
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Lichen Sclerosus: An Atypical Presentation
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