The subject of vitamin D insufficiency and deficiency recently has gained increased attention in the medical literature. Particular concerns have been raised regarding vitamin D levels in individuals with skin of color. Melanin provides at least some degree of protection from UV radiation, which impacts vitamin D production and blood levels in many individuals with skin of color. Additionally, the daily use of sunscreen recommended for all patients also is commonly advised as adjunct treatment of pigmentary and collagen vascular disorders, which are common in skin of color patients, and may interfere with adequate vitamin D levels in this population. Based on 6 key points, this editorial is a call to action for healthcare providers who treat skin of color patients to recognize possible vitamin D insufficiency and deficiency, educate patients regarding diet and supplementation, and promote the investigation of issues regarding vitamin D.