Department

Pediatric Dermatology

Vesiculopustular Eruption in a Neonate With Trisomy 21 Syndrome as a Clue of Transient Myeloproliferative Disorders

Piersigilli F, Diociaiuti A, Boldrini R, Auriti C, Curci M, El Hachem M, Seganti G

Cutis. 2010;85:286-288.

We report the case of a vesiculopustular eruption associated with a transient myeloproliferative disorder (TMD) in a neonate with trisomy 21 syndrome. Examination of a skin biopsy showed a dermal mixed inflammatory infiltrate including atypical megakaryoblasts. As the white blood cell count spontaneously normalized, the eruption disappeared. This case report and review of the literature demonstrates that a vesiculopustular eruption could be an important clue to identify TMD in a neonate.

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