CME

Continuing Medical Education

Scleromyxedema Presenting With Neurologic Symptoms: A Case Report and Review of the Literature

Marshall K, Klepeiss SA, Ioffreda MD, Helm KF

Cutis. 2010;85:137-140.

Scleromyxedema is a rare variant of lichen myxedematosus. In addition to cutaneous manifestations, scleromyxedema often presents with systemic manifestations, including dysphagia, proximal muscle weakness, central nervous system disturbances, encephalopathy, and restrictive lung disease. It is almost always associated with paraproteinemia, usually IgG with γ light chains. We review the literature on scleromyxedema associated with neurologic symptoms and present a case of a 49-year-old woman with encephalopathy attributable to scleromyxedema.

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