We report a case of blastomycosislike pyoderma (BLP), also known as pyoderma vegetans, in a 75-year-old woman. The patient initially presented with multiple lesions, some classic and others with highly uncharacteristic morphology. The appearance of unusual purulent hornlike lesions on both cheeks delayed recognition of the disease. The diagnosis of BLP is contingent on the fulfillment of 6 diagnostic criteria and the disease is highly refractory to current treatment strategies. We review the present understanding of disease pathology and available therapeutic modalities.