Molluscum contagiosum (MC) is a skin infection caused by the double-stranded DNA virus of the family Poxviridae that typically presents as flesh-colored asymptomatic umbilicated papules. Plantar MC is uncommon. We describe a 23-year-old man who presented with multiple plantar MC. We also summarize the epidemiologic features of the 34 previously reported patients with plantar MC and discuss the clinical characteristics, differential diagnosis, and treatment of plantar MC. The patients were immunocompetent and the median age at diagnosis was 21 years. Although the plantar MC were asymptomatic in some individuals, a common presenting symptom was pain while walking. Patients had 1 lesion (23/35), 2 lesions (5/35), 3 lesions (4/35), or more than 5 lesions (3/35). Giant MC (≥1 cm in diameter) was observed in more than 75% (a minimum of 27/35) of patients. At the initial patient evaluation, plantar verruca often was suspected; subsequently, light and/or electron microscopy of the plantar lesion confirmed the diagnosis of plantar MC. Removal or destruction of the lesion resulted in definitive treatment of the plantar MC.